Registration Dossier
Registration Dossier
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EC number: 247-953-0 | CAS number: 26747-90-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no recording of body weights and necropsy findings
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2,4-dioxo-1,3-diazetidine-1,3-bis(methyl-m-phenylene) diisocyanate
- EC Number:
- 247-953-0
- EC Name:
- 2,4-dioxo-1,3-diazetidine-1,3-bis(methyl-m-phenylene) diisocyanate
- Cas Number:
- 26747-90-0
- Molecular formula:
- C18H12N4O4
- IUPAC Name:
- bis(3-isocyanato-4-methylphenyl)-1,3-diazetidine-2,4-dione
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino rats
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS: no details specified
ENVIRONMENTAL CONDITIONS: no details specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: oil
- Details on oral exposure:
- no details specified
- Doses:
- 500, 1000, 2000, 2500 mg/kg bw
- No. of animals per sex per dose:
- 3 males/dose
- Control animals:
- no
- Details on study design:
- no details specified
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived the treatment.
- Clinical signs:
- other: At doses of 1000 mg/kg bw and above poor general condition and accelerated breathing were observed in all animals.
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
Table 1: Toxicological results after single oral application of Desmodur TT to male rats
| Sex | Dose (mg/kg bw) | Toxicological results |
| male | 500 | 0 / 0 / 3 |
| 1000 | 0 / 3 / 3 | |
| 2000 | 0 / 3 / 3 | |
| 2500 | 0 / 3 / 3 |
Toxicological results:
number of dead animals / number of animals with signs after treatment / number of animals treated
Applicant's summary and conclusion
- Executive summary:
The oral LD50 of Desmodur TT is > 2500 mg/kg bw for male albino rats. At 1000 mg/kg bw and above all animals showed poor general condition and accelerated breathing. The NOEL with regard to mortality and clinical signs is 500 mg/kg bw for male rats.
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