2(1H)-Pyridinone, 4-amino-5-methyl-

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-03-21 to 2018-05-24

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Test guideline 3

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

GLP compliance:

no

Type of method:

method according to Siwoloboff

Test material

Test material information

Constituent 1

Reference substance name:

4-amino-5-methyl-1,2-dihydropyridin-2-one

EC Number:

682-818-3

Cas Number:

95306-64-2

Molecular formula:

C6 H8 N2 O

IUPAC Name:

4-amino-5-methyl-1,2-dihydropyridin-2-one

Test material form:

solid

Results and discussion

Boiling point

Key result

Atm. press.:

101.3 kPa

Decomposition:

yes

Decomp. temp.:

ca. 380 °C

Any other information on results incl. tables

The determination of the boiling point was performed by visual judgement using the capillary.

At about 310 °C to 390 in the preliminary tests, the colour changing to black was observed and the test item melted.

Due to this observation, a decomposition process at 380 °C is assumed.

A clear normal boiling point, as defined in the guideline with a current stream of bubbles evolving from the capillary, was not observed

Applicant's summary and conclusion

Conclusions:

In conclusion, for 4-Amino-5-methylpyridinon no boiling point according to the criteria described in the guideline could be observed up to 400 °C. The atmospheric pressure was 100.13 kPa.

Executive summary:

Title: 4-Amino-5-methylpyridinon: Determination of the Boiling Point

This study was based on the procedures indicated by the following internationally accepted methods:

-Commission Regulation (EC) No.440/2008 laying down test methods pursuant to Regulation (EC) No.1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) (originally published as Council Regulation (EC) No.440/2008, corrigendum according to Official Journal of the European Union (EN) dated June 3, 2008, L 143/55), Annex, Part A, A.2.: “Boiling Temperature”, Official Journal of the European Union, L 142, Volume 51, 31 May 2008

-Organization for Economic Co-operation and Development (OECD), Guidelines for Testing of Chemicals, Guideline No.103, “Boiling Point”, adopted July 27, 1995

-Product Properties Test Guideline OPPTS 830.7220 of the United States Environment Protection Agency (EPA), August 1996

Purpose: The purpose of this study was to evaluate the boiling point of

4-Amino-5-methylpyridinon by the capillary method using an electronic controlled heating system.

Results:           

The determination of the boiling point was performed by visual judgement using the capillary method.

At about 310 °C to 390 in the preliminary tests, the colour changing to black was observed and the test item melted.

Due to this observation, a decomposition process at 380 °C is assumed.

A clear normal boiling point, as defined in the guideline with a current stream of bubbles evolving from the capillary, was not observed.

Conclusion:

In conclusion, for 4-Amino-5-methylpyridinon no boiling point according to the criteria described in the guideline could be observed up to 400 °C. The atmospheric pressure was 100.13 kPa.

This study is classified acceptable and satisfies the guideline requirements for boiling point studies.