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EC number: 682-818-3 | CAS number: 95306-64-2
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-03-21 to 2018-05-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- GLP compliance:
- no
- Type of method:
- capillary method
Test material
- Reference substance name:
- 4-amino-5-methyl-1,2-dihydropyridin-2-one
- EC Number:
- 682-818-3
- Cas Number:
- 95306-64-2
- Molecular formula:
- C6 H8 N2 O
- IUPAC Name:
- 4-amino-5-methyl-1,2-dihydropyridin-2-one
- Test material form:
- solid
Constituent 1
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- >= 292.2 - <= 304 °C
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- ambiguous
- Remarks:
- At 304.0 °C the liquefying point, a complete meniscus is formed at the surface, but an appreciable amount of the sample remains solid, was visual observed. At the end of the test the test item was liquid and black.
- Decomp. temp.:
- 304 °C
- Sublimation:
- no
Any other information on results incl. tables
The determination of the melting point was performed by visual judgement using the capillary method. In the preliminary tests the test item starts melting at 310 °C. The test item showed four stages of melting. The melting started at 292.2 °C (stage A: Beginning of melting / wet point: Fine droplets adhere uniformly on the inside wall of the capillary tube.) At 304.0 °C the last stage D of melting (Liquefying point: A complete meniscus is formed at the surface, but an appreciable amount of the sample remains solid.) was visual observed. At the end of the test the test item was liquid and black; it is assumed that the test item decomposed at 304°C.
Applicant's summary and conclusion
- Conclusions:
- 4-Amino-5-methylpyridinon melted in the range of 292.2 °C to 304.0 °C (565.4 K to 577.2 K).
- Executive summary:
Title:
4-Amino-5-methylpyridinon: Determination of the Melting Point / Melting Range
Purpose:
The purpose of this study was to evaluate the melting point or melting range of 4-Amino-5-methylpyridinon by the capillary method using an electronic controlled heating system.
This study was based on the procedures indicated by the following internationally accepted methods:
Commission Regulation (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) (originally published as Council Regulation (EC) No 440/2008, corrigendum according to Official Journal of the European Union (EN) dated June 3, 2008, L 143/55), Annex V, Part A, A.1.: “Melting /Freezing Temperature”, Official Journal of the European Union, L 142, Volume 51, 31 May 2008
Organization for Economic Co-operation and Development (OECD), Guidelines for Testing of Chemicals, Guideline No.: 102, “Melting Point/Melting Range”, adopted July 27, 1995
Product Properties Test Guideline of the United States Environment Protection Agency (EPA), OPPTS 830.7200 Melting Point / Melting Range, March 1998
Results:
The determination of the melting point was performed by visual judgement using the capillary method. In the preliminary tests the test item starts melting at 310 °C. The test item showed four stages of melting. The melting started at 292.2 °C (stage A: Beginning of melting / wet point: Fine droplets adhere uniformly on the inside wall of the capillary tube.) At 304.0 °C the last stage D of melting (Liquefying point : A complete meniscus is formed at the surface, but an appreciable amount of the sample remains solid.) was visual observed. At the end of the test the test item was liquid and black; it is assumed that the test item decomposed at 304°C. This study is classified acceptable and satisfies the guideline requirements for melting point studies.
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