Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across from an analogue substance for which a guideline study (Klimish 1) is available.
- Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across approach from experimental data (study according to OECD 111) on an analogue substance.
- Specific details on test material used for the study:
- See attached document.
- Transformation products:
- no
- Remarks:
- Results based on a read-across from an analogue substance.
- Details on hydrolysis and appearance of transformation product(s):
- Based on read-across approach from analogue substance, no significant degradation is expected at 50 ºC and at pH 4, 7 and 9. The estimated half-life time is > 1 year and therefore the substance is considered to be hydrolytically stable.
- Key result
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: Based on a read-acrossfrom an analogue substance.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on read-across approach, the substance P-1057 is considered to be hydrolytically stable.
- Executive summary:
Based on experimental data on the analogue substance P0310 where there was no significant degradation at 50ºC, pH 4, 7, 9 and the half-life time was higher than one year (OECD Guideline 111 and GLP) the read-across approach is applied and the substance P-1057 is also considered to be hydrolytically stable.
Reference
Description of key information
Key study: Based on read-across aproach from analogue substance P0310, the substance P-1057 is considered to be hydrolitically stable at environmental conditions (25 ºC).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Key study: Based on read-across aproach from analogue substance P0310 (study performed according to OECD 111 and GLP), the substance P-1057 is considered to be hydrolitically stable at environmental conditions (25 ºC).
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