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Physical & Chemical properties

Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012-12-06
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Determination has been run accordingly to standardized method but without GLP compliance.
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
no
Dissociating properties:
yes
pKa:
ca. 7.6
Temp.:
20 °C
Remarks on result:
other: It is not possible to separately determine the pka1 and pka2 values for this substance in water.
Conclusions:
The dissociation constant is determined to 7.6 at 20 °C. It is not possible to separately determine the pka1 and pka2 values for this substance in water.
Executive summary:

The dissociation constant is determined to 7.6 at 20 °C. It is not possible to separately determine the pka1 and pka2 values for this substance in water.

Description of key information

The dissociation constant is determined to 7.6 at 20 °C. It is not possible to separately determine the pka1 and pka2 values for this substance in water. In a supporting study the pKa values are  predicted to 9.98 and 10.16 for the etherdiamine and 4.77 for the acetate. This at a temperature of 25 °C.

Key value for chemical safety assessment

pKa at 20°C:
7.6

Additional information