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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative databases and safety assessment reports

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
IUCLID DATASET
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID DATASET- EUROPEAN COMMISSION – European Chemicals Bureau- 18–FEB–2000
Reference Type:
other: Authoritative database
Title:
HSDB for the Test Chemical
Author:
U S National Library of Medicine
Year:
2007
Bibliographic source:
Hazardous Substances Data Bank [HSDB], last updated 2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EEC method described in the annex to directive 92/69/EEC, part B, Method B4.
Principles of method if other than guideline:
To assess the skin irritation potential of the test chemical in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium hydrogen glutamate
EC Number:
205-538-1
EC Name:
Sodium hydrogen glutamate
Cas Number:
142-47-2
Molecular formula:
C5H9NO4.Na
IUPAC Name:
Monosodium glutamate
Test material form:
solid
Details on test material:
- Name: Monosodium glutamate
- Name of test material (as cited in study report): L-glutamic acid sodium salt
- Molecular formula: C5H8NNaO4
- Molecular weight: 169.1112 g/mol
- Smiles notation: [C@H](CCC(=O)O)(C(=O)[O-])N.[Na+]
- InChl : 1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
No data available
Observation period:
No data available
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: No data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No signs of irritation observed
Other effects:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The test chemical was described as not irritating in the rabbit test according to the EEC method described in the annex to directive 92/69/EEC, part B, Method B4.
Executive summary:

The dermal irritation potential of the test chemical in rabbits. The study was performed according totest according to the EEC method described in the annex to directive 92/69/EEC, part B, Method B4.

The test chemical was applied to rabbit skin and observed for signs of irritation(dose, duration of exposure and observation period not mentioned),

The test chemical was described as not irritating in the rabbit test.