Registration Dossier
Registration Dossier
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EC number: 205-778-7 | CAS number: 150-90-3
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Principles of method if other than guideline:
- Determination of hydrolysis of test chemical at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH).
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Temp.:
- 50 °C
- Remarks:
- The study was performed at pH 4, 7 and 9, respectively.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- Key result
- Temp.:
- 50 °C
- DT50:
- > 5 d
- Remarks on result:
- other: The study was performed at pH 4, 7 and 9, respectively.
- Details on results:
- The half-life value of test chemical was determined to be > 5 days at pH 4, 7 and 9, respectively at a temperature of 50⁰C. Thus, the test chemical was reported to be hydrolytically stable.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The half-life value of test chemical was determined to be > 5 days at pH 4, 7 and 9, respectively at a temperature of 50⁰C. Thus, based on this, test chemical is considered to be not hydrolysable.
- Executive summary:
The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C and pH of 4, 7 and 9, respectively. The half-life value of test chemical was determined to be > 5 daysat pH 4, 7 and 9, respectively at a temperature of 50⁰C. Thus, based on this, test chemical is considered to be not hydrolysable.
Reference
Description of key information
The half-life of the test chemical was determined at different pH range (from secondary source, 2009). The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C and pH of 4, 7 and 9, respectively. The half-life value of test chemical was determined to be > 5 daysat pH 4, 7 and 9, respectively at a temperature of 50⁰C. Thus, based on this, test chemical is considered to be not hydrolysable.
Key value for chemical safety assessment
Additional information
The half-life of the test chemical was determined at different pH range (from secondary source, 2009). The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C and pH of 4, 7 and 9, respectively. The half-life value of test chemical was determined to be > 5 daysat pH 4, 7 and 9, respectively at a temperature of 50⁰C. Thus, based on this, test chemical is considered to be not hydrolysable.
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
