Diphenyl sulphide

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

Data is from peer-reviewed journal

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

HENRY F. SMYTH, JR., Ph.D., CHARLES P. CARPENTER, Ph.D., CARROL S. WEIL, M.A., URBAN0 C. POZZANI, M.S., and JEAN. A. STRIEGEL, B.S.

Year:

1962

Bibliographic source:

American Industrial Hygiene Association Journal, V.23:2, pages 95-107 1962

Reference 2

Reference Type:

other: authoritative database

Title:

Eye irritation study for Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2)

Author:

GSBL

Year:

2018

Bibliographic source:

GSBL, Joint Substance Data Pool of the German Federal Government and the German Federal States, 2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

The study was conducted to evaluate the acute eye irritation potential of Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2) in albino rabbits.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Diphenyl sulphide

EC Number:

205-371-4

EC Name:

Diphenyl sulphide

Cas Number:

139-66-2

Molecular formula:

C12H10S

IUPAC Name:

(phenylsulfanyl)benzene

Test material form:

liquid

Details on test material:

Name of test material (as cited in study report): Diphenyl sulphide
Molecular formula:C12H10S
Molecular weight:186.277 g/mol
Smiles : c1(Sc2ccccc2)ccccc1
InChI : 1S/C12H10S/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10H
Substance Type: Organic
Physical State: Liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): Phenyl sulfide
- Molecular formula: C12H10S
- Molecular weight: 186.277 g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals / tissue source

Species:

rabbit

Strain:

other: Albino New Zealand

Details on test animals or tissues and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg
- Sex: Male

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): undiluted chemical

VEHICLE (not used)
- Amount(s) applied (volume or weight with unit): No data
- Concentration (if solution): No data
- Lot/batch no. (if required): No data
- Purity: No data

Duration of treatment / exposure:

No data available

Observation period (in vivo):

No data available

Number of animals or in vitro replicates:

No data available

Details on study design:

TEST SITE
- Area of exposure: Eye
- % coverage: No data available
- Type of wrap if used: No data available

REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data available
- Time after start of exposure: No data available

SCORING SYSTEM:
A 10- grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemical. Grade 1 indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 ml, and Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol.

Results and discussion

In vivo

Results

Irritation parameter:

other: corneal necrosis

Basis:

mean

Score:

2

Max. score:

10

Reversibility:

not specified

Remarks on result:

probability of mild irritation

Applicant's summary and conclusion

Interpretation of results:

other: Not irritating

Conclusions:

The test substance Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2) was considered to be not irritating to the rabbit eyes.

Executive summary:

The study was conducted to evaluate the acute eye irritation potential of Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2) in albino rabbits. A score of 2, indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Hence, it was concluded that test substance Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139 -66 -2) was considered to be not irritating to the rabbit eyes.