Registration Dossier
Registration Dossier
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EC number: 216-510-3 | CAS number: 1604-35-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,7,11-trimethyldodecyn-3-ol
- EC Number:
- 216-510-3
- EC Name:
- 3,7,11-trimethyldodecyn-3-ol
- Cas Number:
- 1604-35-9
- Molecular formula:
- C15H28O
- IUPAC Name:
- 3,7,11-trimethyldodec-1-yn-3-ol
- Details on test material:
- - Name of test material (as cited in study report): 3,7,11-trimethyldodecyn-3-ol, CAS: 1604-35-9
- Physical state:
- Analytical purity: 98.8 area-%
- Impurities (identity and concentrations):
- Purity test date:
- Lot/batch No.:
- Stability under test conditions:
- Storage condition of test material:
- Other:
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- 24 hour(s)
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Comment: rinsed after (see exposure time)
Results and discussion
Any other information on results incl. tables
RS-Freetext:
The ocular reactions were assessed approximately 1, 24, 48 and 72 hours after application.
Slight or moderate conjunctival redness, moderate or severe discharge and injected scleral vessels in a circumscribed area were observed in the animals within 24 hours after
application.
The ocular reactions were reversible in all animals within 48 hours after application at latest.
The average score (24 to 72 hours) for irritation was calculated to be 0.0 for corneal opacity, iris and chemosis and 0.1 for conjunctival redness
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- Classification: not irritating
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