Registration Dossier
Registration Dossier
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EC number: 406-260-5 | CAS number: 58834-75-6 BTN; VPO CATALYST
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessed after consultation with the relevant Authority. Data migrated from NONS files provided by Authority contain insufficient information.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Remarks:
- PHARMACO-LSR LTD: EYE; SUFFOLK IP23 7PX
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Vanadyl pyrophosphate
- EC Number:
- 406-260-5
- EC Name:
- Vanadyl pyrophosphate
- Cas Number:
- 58834-75-6
- Molecular formula:
- O9P2V2
- IUPAC Name:
- divanadium(4+) (phosphonatooxy)phosphonate dioxidandiide
- Details on test material:
- - Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 1.0% w/v methylcellulose in distilled water. The substance was administered as a suspension.
- Doses:
- 1474, 2000, 2714, 3684, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 171 mg/kg bw
- 95% CL:
- 1 789 - 2 552
- Remarks on result:
- other: Slope of the mortality curve: 68
- Mortality:
- Male: 1474 mg/kg bw; Number of animals: 5; Number of deaths: 1
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 2714 mg/kg bw; Number of animals: 5; Number of deaths: 4
Male: 3684 mg/kg bw; Number of animals: 5; Number of deaths: 5
Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 1474 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2714 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 3684 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 4 - Clinical signs:
- other: Signs of toxicity related to dose levels: Deaths occurred on days 2,3,4 and 6 (treatment was on day 1). Ante mortem signs comprised lethargy, decreased motor activity, prone posture, ataxia, muscle tremor, bradypnoea, hyperpnoea, piloerection, ungroomed a
- Gross pathology:
- Effect on organs:
Necropsy of decedents showed altered stomach, small intestine and caecum contents and areas of body staining.
Surviving animals showed no significant macroscopic lesion.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- DSD: not classified
CLP: not classified
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