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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: read-across from in vivo study with an analogue
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The analogue ethyl chloroacetate which shares the same functional group with methyl chloroacetate, also has comparable values for the relevant molecular properties for the skin irritation endpoint.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
Read-across approach from in vivo study with the analogue ethyl chloroacetate
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Based on the experimental results obtained with the analogue ethyl chloroacetate (reported under the endpoint record 07.03.01_02), which is considered to be irritant, and applying the read-across approach, the substance methyl chloroacetate is also considered as irritant to the skin.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant)
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on the experimental results obtained with the analogue ethyl chloroacetate (reported under the endpoint record 07.03.01_02), which is considered to be irritant, and applying the read-across approach, the substance methyl chloroacetate is also considered as irritant to the skin.
Executive summary:

Based on the experimental results obtained with the analogue ethyl chloroacetate (reported under the endpoint record 07.03.01_02), which is considered to be irritant, and applying the read-across approach, the substance methyl chloroacetate is also considered as irritant to the skin.