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EC number: 217-038-0 | CAS number: 1726-23-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant study conducted in accordance with internationally recognised test methods. For read across justification see Section 13.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Trioctyl trimellitate
- IUPAC Name:
- Trioctyl trimellitate
- Details on test material:
- - Name of test material (as cited in study report): Trioctyl benzene-1,2,4-tricarboxyiate
- Molecular formula (if other than submission substance): C33 H54 O6
- Molecular weight (if other than submission substance): 546.79
- Smiles notation (if other than submission substance): O=C(OCCCCCCCC)c(ccc(c1C(=O)OCCCCCCCC)C(=O)OCCCCCCCC)c1
- InChl (if other than submission substance): 1S/C27H42O6/c1-3-5-7-9-11-12-14-16-20-33-27(31)23-18-17-22(21-24 (23)25(28)29)26(30)32-19-15-13-10-8-6-4-2/h17-18,21H,3-16,19-20H2,1-2H3, (H,28,29)
- Structural formula attached as image file (if other than submission substance): see 89-04-3 structure.png
- Physical state: liquid
- Analytical purity: => 99.0%
- Lot/batch No.: C-120
- Stability under test conditions: Stated to be stable
- Storage condition of test material: Ambient conditions
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crj:CD (SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Japan
- Age at study initiation: 5 weeks
- Weight at study initiation: males: 116-127 g; females: 97-108 g
- Fasting period before study: 18 hours
- Housing: 5 same sex in stainless steel breeding cages
- Diet (e.g. ad libitum): yes, except during pre-dose fasting period
- Water (e.g. ad libitum): yes
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23+/- 2 degrees C
- Humidity (%): 55+/- 10
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12: 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% w/v
- Amount of vehicle (if gavage): 10 mL/kg
- Justification for choice of vehicle: Substance is not miscible in aqueous vehicles but is water miscible in oil
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
DOSAGE PREPARATION (if unusual): liquid test substance mixed with vehicle - Doses:
- 2000 mg/kg (based on findings of preliminary study in which doses of 1000 and 2000 mg/kg did not cause mortality).
- No. of animals per sex per dose:
- 5 males & 5 females
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: frequently for 6 hours on day of dosing then daily
- Necropsy of survivors performed: yes
- Other examinations performed: body weight - Days 1, 2, 4, 8, 11 and 15 - Statistics:
- Student t-test applied to bodyweight data control vs. test groups
Results and discussion
- Preliminary study:
- In preliminary study 1000 and 2000 mg/kg did not cause mortality.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No deaths occurred
- Mortality:
- None in controls or test group
- Clinical signs:
- other: Mucoid faeces were seen in animals from both control and test groups 1-3 hours after dosing. The incidence between groups was similar.
- Gross pathology:
- There were no abnormalities noted in any animal from either control or treatment group.
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose (LD50) in the rat was established at > 2,000 mg/kg for both sexes.
- Executive summary:
Acute oral toxicity has been investigated in the rat using methods decribed in OECD TG 401. No mortality or effects of treatment occurred following administration of a single dose at a level of 2000 mg/kg body weight. The median lethal dose (LD50) in the rat is therefore in excess of 2000 mg/kg
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