Registration Dossier
Registration Dossier
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EC number: 217-038-0 | CAS number: 1726-23-4
Endpoint summary
Administrative data
Description of key information
Additional information
Acute studies of immobilisation in Daphnia, algal growth inhibition and toxicity to fish have been undertaken either on the registered substance itself or on structural analogues of the registered substance. Dissolution/dispersion agents were used to increase concentration of two of the substances in the test medium. In these studies the EC50 (48h) was determined to be >100 mg/L and the NOEC was 100 mg/L. Other studies investigated effects of a water accommodated fraction. No toxicity resulted from short-term exposure to the substances examined. Microbial respiration inhibition tests have investigated the effects of two structural analogues of the registered substance. No inhibition was observed in either test.
Chronic toxicity to Daphnia has been investigated on the registered substance itself and on three structural analogues of the registered substance. Dissolution/dispersion agents were used to increase concentration of two of the substances in the test medium. The selected (critical) study on the registered substance itself investigated the effects of a water accommodated fraction. A prolonged exposure study of toxicity to fish on a structural analogue of the registered substance has been conducted according to OECD Test Guideline No. 204. It is recognised that the duration of the OECD TG 204 test is shorter than that currently accepted for investigating long-term toxicity in fish. Waiving of repeat or additional testing is proposed based both on the lack of effects seen in the 14-day fish study and chronic Daphnia reproduction studies together with considerations regarding adequate justification for the use of vertebrate species for experimental purposes. No effects were observed in the selected studies.
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