1,6-Naphthyridine-3-carboxylic acid, 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)

GLP compliance:

no

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Specific details on test material used for the study:

PPS sample number: 124089

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

The test substance melted when approached by the ignition flame.

Interpretation of results:

not classified based on GHS criteria

Conclusions:

Carboxy-TH-naphthyridin is classified as a not readily combustible solid when tested according to UN-MTC Procedure N.1.

Executive summary:

The test was performed as stipulated in UN test procedure ‘Recommendations on the Transport of Dangerous Goods - Manual of Tests and Criteria’ (UN-MTC), Part III, sub-section 33.2.1.4.1, Test N.1 ‘Test method for readily combustible solids’.

Carboxy-TH-naphthyridin was formed into a powder train about 250 mm long by 20 mm wide by 10 mm high on a non-combustible, non-porous and low heat-conducting base plate. 30 – 40 mm beyond the 100 mm timing zone, 1 mL of a wetting solution was added to the pile. A hot flame from a gas burner was applied to one end of the powder train until the powder ignites or for a maximum of 2 minutes. A preliminary screening test was performed to determine if propagation by burning with flame or smoldering occurs without wetted zone.

The substance in its delivery state was measured. The test substance melted when approached by the ignition flame. The substance did not burn up. No further testing was required.

Carboxy-TH-naphthyridin is classified as a not readily combustible solid when tested according to UN-MTC Procedure N.1.

Reference 2

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

Reference 3

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)

GLP compliance:

no

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Specific details on test material used for the study:

Sample: 122071

Test procedure:

25 mm sample cube at 140°C

Max. temp. reached:

158

Result:

negative outcome (no effect observed)

Remarks:

a brown melt remained in the basket

Test procedure:

other: 25 mm sample cube at 123 °C

Max. temp. reached:

125

Result:

negative outcome (no effect observed)

Test procedure:

other: 50 mm sample cube 119 °C

Max. temp. reached:

119

Result:

negative outcome (no effect observed)

Test procedure:

other: 100 mm sample cube at 108 °C

Max. temp. reached:

113

Result:

negative outcome (no effect observed)

Test procedure:

other: 125 mm sample cube at 106 °C

Max. temp. reached:

195

Result:

positive outcome (effect observed)

Extrapolation shows that critical temperature of the substance for self-heating in volumes of 27 m^3 is distinct above 50 °C.

Interpretation of results:

not classified based on GHS criteria

Conclusions:

Extrapolation of the received values shows that the critical temperature of the substance for self-heating in volumes of 27 m^3 is distinct above 50 °C. Thus, Carboxy-TH-naphthyridin is not classified as self-heating substance.

Executive summary:

According to UN N. 4, a Bowes-Cameron-Cage-Test was performed: Carboxy-TH-naphthyridin was filled in a basket (16 mL) and stored in a drying oven at a constant temperature of 140 °C for at least 24 h.

Afterwards, a volume dependent heat storage was perfomed:

The substance was filled in a basket and kept in a drying oven. The temperature was increased gradually until a visible exothermic effect occured. The sample temperatur was measured by a thermal element. As reference temperature a thermal element was in the headspace ot the drying oven. During the procedure the temperature was recorded computer based.

Extrapolation of the received values shows that the critical temperature of the substance for self-heating in volumes of 27 m^3 is distinct above 50 °C. Thus, Carboxy-TH-naphthyridin is not classified as self-heating substance.

Reference 4

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the organic substance does not contain metals or metalloids and hence, the classification procedure does not need to be applied

Description of key information

a) flammability: Carboxy-TH-naphthyridin is classified as a not readily combustible solid when tested according to UN-MTC Procedure N.1.

b) pyrophoric properties: Carboxy-TH-naphthyridin is known to be stable in contact with air at room temperature for prolonged periods of time.

c) self-heating: Extrapolation of the received values shows that the critical temperature of the substance for self-heating in volumes of 27 m^3 is distinct above 50 °C. Thus, Carboxy-TH-naphthyridin is not classified as self-heating substance.

d) contact with water: Carboxy-TH-naphthyridin does not contain metals or metalloids and hence, the classification procedure does not need to be applied.

Key value for chemical safety assessment

Flammability:

not classified