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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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REACH

1,6-Naphthyridine-3-carboxylic acid, 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-

EC number: 810-200-7 | CAS number: 1050477-45-6

Life Cycle description
Uses advised against

Toxicological information

Endpoint summary

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Endpoint conclusion:: no study available

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:: no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:: no study available

Additional information

No studies are availabe for Carboxy-TH-naphthyridin (CAS No. 1050477-45-6). According to expert opinion a (weaker) pharmacological action of the compound cannot be ruled out due to the structural similarity to the active pharmaceutical ingredient (API; CAS No. 1050477-31-0). As the major findings of the toxicological studies with the API were considered to be related to its pharmacological action (selective, non steroidal mineralocorticoid receptor (MR) antagonist) a similar tolerability of the precursor is to be assumed. Although no in vitro assays, which reveal that Carboxy-TH-naphthyridin acts as (MR) antagonist, are available.

The acute oral toxicity of the API was determined to be: LD50 cut-off value = 300 mg/kg bw in rats according to OECD TG 423.Thus a classification in Category 3 is warranted.

Justification for classification or non-classification

According to the corresponding active pharmaceutical ingredient (CAS No. 1050477-31-0) the substance is classified in Category 3 (oral route).

Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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