Registration Dossier
Registration Dossier
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EC number: 205-003-2 | CAS number: 130-95-0
Endpoint summary
Administrative data
Description of key information
Additional information
Long-term toxicity of quinine to fish:
This experimental study was published by Ali, 2012. A test of the toxicity of quinine sulphate on zebrafish embryosDanio reriowas performed in a static system. The LC50 (96 h) of the read across substance quinine sulphate for zebrafish embryos is 562.4 mg/L. According to this, the LC50 (96 h) of quinine is 431.85 mg/L. After exposure duration of 24 h, 48 h and 72 h no embryos had died.
Short-term toxicity of quinine to invertebrates Daphnia magna:
In the experimental study published by Guilhermino, 2000 the EC50 of the read across substance quinine sulphate for Daphnia magna was determined. The EC50 (24 h) of quinine sulphate for Daphnia magna is 44.8 mg/l. According to this, the EC50 of quinine is 34.4 mg/L. In an own experimental study the EC50 for 48 h of the read across substance quinine sulphate for Daphnia magna is 91.93.mg/l. According to this, the EC50 of quinine is 70.59 mg/l. In the study published by Morrow, 2001 the EC50 of the read across substance quinine hydrochloride for Daphnia pulex was determined with a petri-dish bioassay method and a multiwell bioassay method. The EC50 (24 h) of quinine hydrochlorideis 28.3 mg/l. According to this, the EC50 of quinine is 25.4 mg/L.
Short-term toxicity of quinine to green algae Dunaliella salina:
This experimental study was published by Moreno-Garrido, 2001. In this publication, the toxicity for green algae Dunaliella salina was determined for 72 h in saltwater. The determined EC50 of the read across substance quinine sulphate is 14.5 mg/L. According to this, the EC50 of quinine is 11.13 mg/L.
Toxicity of quinine to aquatic plants:
In the publication of Wink, 1992 the toxicity of quinine to Lemna gibba was determined for 6 days. At a concentration of 0.4% quinine lead to death. Bleaching of Lemna gibba was observed at a concentration of 0.04%.
Toxicity to microorganisms:
In the study published by Wink, 1998 the bacterial growth inhibiton of Bacillus subtilis, Escherichia coli and Serratia marcesens was determined. The IC100 of quinine of all three Bacteria species is 5 mM (1.62 g/L). Quinine has antibacterial activity.
In the experimental study published by Divo, 1985 the IC50 for Plasmodium falciparum was determined with a high and a low O2 tension for 96 h. The IC50 for Plasmodium falciparum at a high O2 tension is 0.015 mg/l and the IC50 at a low O2 tension is 0.032 mg/l. Quinine is effective in vitro against the malaria parasites Plasmodium falciparum.
Toxicity of quinine to ciliates:
This experimental study was published by Moreno-Garrido, 2001. In this publication, the toxicity of quinine sulphate to ciliates was determined for 24 h in saltwater. The determined LC100 of the read across substance quinine sulphate is 12 -14 mg/L. According to this, the LC100 of quinine is 9.2 - 10.7 mg/L.
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