Registration Dossier
Registration Dossier
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EC number: 209-693-6 | CAS number: 590-90-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-hydroxybutan-2-one
- EC Number:
- 209-693-6
- EC Name:
- 4-hydroxybutan-2-one
- Cas Number:
- 590-90-9
- Molecular formula:
- C4H8O2
- IUPAC Name:
- 4-hydroxybutan-2-one
- Details on test material:
- Name of the test substance used in the study report: Ketobutanol (= 4-Hydroxybutan-2-on)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean weight for male animals: 246 g, female animals: 198 g
The animals were offered Herilan MRH-Kraftfutter and water ad libitum.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The product was applied to the clipped skin of the back and flank.
The hair was removed from the dorsal and lateral parts of the trunk using electric clippers about 15 to 24 hours before the application. Only animals with healthy and intact skin were used for the study.
The test substance was applied uniformly to an area of about 50 cm2. The treated area of skin was then covered with an inert foil, which was secured in
position with adhesive tape. The bandage was removed after a 24-hour period of contact; subsequently the compound was washed oft with warm water and dried with cellulose. - Duration of exposure:
- 24 h
- Doses:
- 2000 and 4000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Mortality within 14 days
Signs of systemic toxicity and local changes
Necropsy of the animals that died intercurrently and of those sacrificed by carbon dioxide at the end of the observation period.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: Signs of systemic toxicity: dyspnea, apathy, excitation, poor general state. Local changes: 4000 mg/kg: After 24 hours severe reddening, partly extreme severe spotted-necrotic, severe edema. Female animals severe spotted-anemic. After 7 days the male ani
- Gross pathology:
- nothing abnormal detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
