Registration Dossier
Registration Dossier
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EC number: 209-693-6 | CAS number: 590-90-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only orientating information about the inhalation hazard
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
Test material
- Reference substance name:
- 4-hydroxybutan-2-one
- EC Number:
- 209-693-6
- EC Name:
- 4-hydroxybutan-2-one
- Cas Number:
- 590-90-9
- Molecular formula:
- C4H8O2
- IUPAC Name:
- 4-hydroxybutan-2-one
- Details on test material:
- Name of the test substance used in the study report: 1-Hydroxy-2-oxo-butan (Ketobutanol)
(contains impurities of methylvinylketon)
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Remarks on duration:
- 3 and 10 min
- No. of animals per sex per dose:
- 12
- Control animals:
- no
Results and discussion
- Mortality:
- 3 min: 0/12
10 min: 12/12 - Clinical signs:
- other: intense attempts to escape, severe mucosal irriations, breathlessness, gasping, after study ending staggering and abdominal position or orthopnea
- Gross pathology:
- partly emphysema, terminal lung edema and minor hydrothorax
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
