Registration Dossier
Registration Dossier
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EC number: 942-741-0 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
- Reference Type:
- secondary source
- Title:
- Fragrance material review on alpha-iso-methylionone
- Author:
- Lapczynski A et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S280–S289
- Reference Type:
- publication
- Title:
- A toxicologic and dermatologic assessment of ionones when used as fragrance ingredients
- Author:
- Belsito D et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S130–S167
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Test material (0.1 ml) was instilled into the right eye of 3 albino rabbits with no further treatment. The untreated left eye served as a control. Both eyes were examined every 24 hours for 4 days and on day 7. Scoring was according to the Draize scale for ocular lesions.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
- EC Number:
- 204-846-3
- EC Name:
- 3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
- Cas Number:
- 127-51-5
- Molecular formula:
- C14H22O
- IUPAC Name:
- 3-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: stated as "albino"
Test system
- Vehicle:
- not specified
- Controls:
- other: left eye
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): 12.5 % - Duration of treatment / exposure:
- single application, substance remains in eye
- Observation period (in vivo):
- Both eyes were examined every 24 hours for 4 days and on day 7.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM: acc. Draize scale for ocular lesions
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- >= 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- > 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 d
Any other information on results incl. tables
12.5 %: irritant effects
- intense conjunctival irritation from days 1 to 4 involving chemosis and discharge that cleared by day 7
- no corneal opacity or iris congestion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
