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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V (Buehler test)
GLP compliance:
yes
Type of study:
Buehler test

Test material

Constituent 1
Chemical structure
Reference substance name:
Octasodium 2-(8-(4-chloro-6-(3-((4-chloro-6-(3,6-disulfonato-2-(1,5-disulfonatonaphthalen-2-ylazo)-1-hydroxynaphthalen-8-ylamino)-1,3,5-triazin-2-yl)aminomethyl)phenylamino)-1,3,5-triazin-2-ylamino)-3,6-disulfonato-1-hydroxynaphthalen-2-ylazo)naphthalene-1,5-disulfonate
EC Number:
413-550-5
EC Name:
Octasodium 2-(8-(4-chloro-6-(3-((4-chloro-6-(3,6-disulfonato-2-(1,5-disulfonatonaphthalen-2-ylazo)-1-hydroxynaphthalen-8-ylamino)-1,3,5-triazin-2-yl)aminomethyl)phenylamino)-1,3,5-triazin-2-ylamino)-3,6-disulfonato-1-hydroxynaphthalen-2-ylazo)naphthalene-1,5-disulfonate
Cas Number:
142068-96-0
Molecular formula:
C53H28Cl2N14Na8O26S8
IUPAC Name:
octasodium 5-[(4-chloro-6-{[4-({[4-chloro-6-({7-[2-(1,5-disulfonaphthalen-2-yl)diazen-1-yl]-8-hydroxy-3,6-disulfonaphthalen-1-yl}amino)-1,3,5-triazin-2-yl]amino}methyl)phenyl]amino}-1,3,5-triazin-2-yl)amino]-3-[2-(1,5-disulfonaphthalen-2-yl)diazen-1-yl]-4-hydroxynaphthalene-2,7-disulfonate
Constituent 2
Reference substance name:
604-270-6
EC Number:
604-270-6
IUPAC Name:
604-270-6

In vivo test system

Test animals

Species:
other: Guinea pig/ Alpk: Dunkin Hartley

Study design: in vivo (non-LLNA)

Induction
Concentration / amount:
Concentration of test material and vehicle used at induction: 75%(w/v), corresponding to approx. 400mg, in water.
Concentration of test material and vehicle used for each challenge: 75%, 30%, 10% and 3%(w/v) in water.
Challenge
Concentration / amount:
Concentration of test material and vehicle used at induction: 75%(w/v), corresponding to approx. 400mg, in water.
Concentration of test material and vehicle used for each challenge: 75%, 30%, 10% and 3%(w/v) in water.
No. of animals per dose:
Number of animals in test group: 20
Number of animals in negative control group: 10

Results and discussion

Any other information on results incl. tables

Maximum concentration not causing irritating effects in prelim.

Signs of irritation during induction: Staining prevented assessment of erythema. Signs of slight irritation (skin scabbing/thickening) observed in 2 test animals.

Evidence of sensitisation of each challenge concentration: None.

Other observations: Following challenge, staining prevented assessment of 1 test animal challenged with 75% dose; 2 test animals/10% dose; and 5 test animals and 2 controls/3% dose.

Applicant's summary and conclusion

Interpretation of results:
other: not classified