Registration Dossier
Registration Dossier
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EC number: 456-350-3 | CAS number: 878665-13-5
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- From 19 to 21 April 2006
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study was performed according to EU Method C7 and OECD guideline 111 with GLP statement. This study is not valid, quality criteria were not met: recovery of analysis was lower than 70% (mean recovery: 66.6% at pH 4, 65% at pH 7 and 81.7% at pH 9). This study is technically not feasible.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 30th August 2005
Test material
- Reference substance name:
- (3S)-3-(dodecylthio)-1-[(1S,2R)-2,6,6-trimethyl-3-cyclohexen-1-yl]-1-butanone
- Molecular formula:
- C25 H46 O S
- IUPAC Name:
- (3S)-3-(dodecylthio)-1-[(1S,2R)-2,6,6-trimethyl-3-cyclohexen-1-yl]-1-butanone
- Reference substance name:
- (3R)-3-(dodecylthio)-1-[(1S,2R)-2,6,6-trimethyl-3-cyclohexen-1-yl]-1-butanone
- Molecular formula:
- C25 H46 O S
- IUPAC Name:
- (3R)-3-(dodecylthio)-1-[(1S,2R)-2,6,6-trimethyl-3-cyclohexen-1-yl]-1-butanone
- Reference substance name:
- (3S)-3-(dodecylthio)-1-[(1R,2S)-2,6,6-trimethyl-3-cyclohexen-1-yl]-1-butanone
- Molecular formula:
- C25 H46 O S
- IUPAC Name:
- (3S)-3-(dodecylthio)-1-[(1R,2S)-2,6,6-trimethyl-3-cyclohexen-1-yl]-1-butanone
- Reference substance name:
- (3R)-3-(dodecylthio)-1-[(1R,2S)-2,6,6-trimethyl-3-cyclohexen-1-yl]-1-butanone
- Molecular formula:
- C25 H46 O S
- IUPAC Name:
- (3R)-3-(dodecylthio)-1-[(1R,2S)-2,6,6-trimethyl-3-cyclohexen-1-yl]-1-butanone
- Test material form:
- liquid
- Details on test material:
- - Physical state: colourless to pale yellow slightly viscous liquid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
- Specific details on test material used for the study:
- - Storage condition of test material: Approximately 4 °C under nitrogen in the dark
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Estimation method (if used):
- The concentration of the sample solutions (g/L) was calculated using the equation below:
C.spl = (P.spl/P.std) * C.std * D * (1/1000)
Where:
C.spl = sample concentration (g/L)
P.spl = mean peak area of sample solution
P.std = mean peak area of standard solution, corrected to nominal standard concentration
C.std = nominal standard concentration (3.0 mg/L)
D = sample dilution factor (0.0125)
Duration of testopen allclose all
- Duration:
- 144 h
- pH:
- 4
- Initial conc. measured:
- 0.043 mg/L
- Duration:
- 168 h
- pH:
- 7
- Initial conc. measured:
- 0.052 mg/L
- Duration:
- 120 h
- pH:
- 9
- Initial conc. measured:
- 0.038 mg/L
Results and discussion
- Transformation products:
- not measured
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 66.6
- pH:
- 4
- Temp.:
- 50 °C
- % Recovery:
- 65
- pH:
- 7
- Temp.:
- 50 °C
- % Recovery:
- 81.7
- pH:
- 9
- Temp.:
- 50 °C
Dissipation DT50 of parent compoundopen allclose all
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Remarks on result:
- other: estimation
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Remarks on result:
- other: estimation
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Remarks on result:
- other: estimation
Any other information on results incl. tables
See the mean peak area relating to the standard and samples solutions, in "attached background material".
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
- Conclusions:
- Invalid study. The half-life at 25°C was estimated > 1 year at pH 4, 7 and 9.
- Executive summary:
Assessment of hydrolytic stability of the test item was carried out using Method C7 of Commission Directive 92/69/EEC and Method 111 of the OECD Guidelines for testing of chemicals, 13 April 2004.
The results are as follows:
pH 4: estimated half-life at 25°C > 1 year.
pH 7: estimated half-life at 25°C > 1 year.
pH 9: estimated half-life at 25°C > 1 year.
This study is not valid, quality criteria were not met: recovery of analysis was lower than 70% (mean recovery: 66.6% at pH 4, 65% at pH 7 and 81.7% at pH 9). This study is technically not feasible.
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