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EC number: 456-350-3
CAS number: 878665-13-5
7.3.2/1: Irritant/corrosive response data each animals at each
observation time up to removal from the test
Score at time point / Reversibility
0 / 0 / 0
1 / 1 / 2
1 / 1 / 1
0 / 0 / 1
Average 24h, 48h, 72h
0.7 / 0.7 / 0.7
0 / 0 / 0.7
Average time (unit) for reversion
Reversibility: c. = completely reversible; n.c. = not completely
reversible; n. = not reversible
an eye irritation study performed according to the OECD guideline No.
405, and in compliance with GLP, 0.1 mL of undiluted test material was
instilled into the right eye of 3 New Zealand White Rabbit. The eyes
were not rinsed after the instillation of the test item. The left eye
of each rabbit served as control. Animals were observed at 1, 24, 48
and 72 hours after dosing under a standard light source. The reactions
in the conjunctiva (redness, chemosis and discharge), the iris and the
cornea (opacity and area involved) were scored according to the Draize
to moderate conjunctival irritation was noted in all treated eyes one
hour after treatment.
treated eyes appeared normal at the 72-hour observation.
calculated mean score for each individual lesion for each animals
within 3 scoring times (24, 48 and 72 h) were 0.7/0.7/0.7 for redness,
0.0/0.0/0.7 for chemosis and 0.0/0.0/0.0 for discharge,
iris and corneal lesions.
the test conditions, the test material is not classified as irritating
to eyes according to the Regulation (EC) No. 1272/2008 (CLP) and to
study is considered as acceptable and satisfies the requirement for
eye irritation endpoint.
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