Registration Dossier
Registration Dossier
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EC number: 253-425-0 | CAS number: 37247-91-9
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
Description of key information
Calcium magnesium oxide (Neutralac QM3):
Total Dustiness (airborne fraction): 73.31 mg/g (experimental result, DMT Report).
MMAD (bimodal distribution) of airborne fraction: MMAD1 = 6.65 µm (19.9 %) , MMAD2 = 32.27 µm (80.1 %) (distribution fitted to cascade impactor data, percentage in parentheses indicates weighting factor).
GSD of MMAD: GSD1 = 2.12 µm, GSD 2 = 1.49 µm
Fractional deposition in human respiratory tract (MPPD model, based on calculated MMAD):
Head (ET): 49.2 %; Tracheobronchial (TB): 0.3 %; Pulmonary (PU): 0.9 %
Calcium magnesium oxide 20 - 40 mm:
Total Dustiness (airborne fraction): 1.24 mg/g (experimental result, DMT Report).
MMAD (bimodal distribution) of airborne fraction: MMAD1 = 5.36 µm (29.9 %) , MMAD2 = 54.01 µm (70.1 %) (distribution fitted to cascade impactor data, percentage in parentheses indicates weighting factor).
GSD of MMAD: GSD1 = 1.85 µm, GSD 2 = 4.02 µm
Fractional deposition in human respiratory tract (MPPD model, based on calculated MMAD):
Head (ET): 52.0 %; Tracheobronchial (TB): 0.7 %; Pulmonary (PU): 2.0 %
Additional information
For the evaluation of this endpoint, two grades of calcium magnesium oxide (Neutralac QM3 and calcium magnesium oxide 20 - 40 mm) were investigated according to national standard (DIN 55992 -1:2006, modified Heubach method). The respective results are used as key information, supported by data from a guideline compliant study (OECD 110).
The key studies were selected based on the fact that these studies consider the airborne fraction of calcium magnesium oxide, which is exposure-related and relevant for workplace condition. In the other study, used as supportive information, the airborne fraction of calcium magnesium oxide was not determined, but the total of the substance fed in a cascade impactor. This is not exposure-related and not relevant for workplace conditions.
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