Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

There is no indication for genotoxic/mutagenic effects of either burnt dolomitic lime or other calcium or magnesium salts in the available in vitro studies. Furthermore, supportive information is available from comet assays on Ca(OH)2-containing endodontic materials, provided in section 7.12 of the technical dossier (Ribeiro, 2004; Ribeiro, 2005; da Silva, 2007): The results were invariably negative with respect to DNA breakage. This is applicable to calcium contained in burnt dolomitic lime by read-across

Finally, calcium and magnesium are essential mineral nutrients omnipresent in the human body, with daily dietary requirements for adults of approximately 1000 mg (calcium) and 220-260 mg (magnesium), varying by developmental status and age.

Short description of key information:
Calcium magnesium oxide is not genotoxic.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

In view of the omnipresence and essentiality of Ca and Mg, and of the physiological non-relevance of any pH shift induced by lime in aqueous media, burnt dolomitic lime is obviously void of any genotoxic potential.

Classification for genotoxicity is not warranted.