Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 223-768-0 | CAS number: 4062-46-8
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: screening tests
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well repoted GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 17β-hydroxy-1α-methyl-5-αandrostan-3-one acetate
- EC Number:
- 223-768-0
- EC Name:
- 17β-hydroxy-1α-methyl-5-αandrostan-3-one acetate
- Cas Number:
- 4062-46-8
- Molecular formula:
- C22H34O3
- IUPAC Name:
- 1-methyl-3-oxoandrostan-17-yl acetate
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- ca. 28 d
Results and discussion
% Degradation
- Value:
- 7
- Sampling time:
- 28 d
- Details on results:
- no toxicity to sewage sludge microorganisms was observed. Therefore, the test substance is not ready biodegradable.
Applicant's summary and conclusion
- Interpretation of results:
- under test conditions no biodegradation observed
- Executive summary:
The biodegradability of the test substance was studied in a CO2 evolution test according to OECD301B. The test substance and the reference substance sodium acetate was incubated with diluted activated sludge from a municipal sewage treatment plant over a period of 28 days. The test substance was only slightly degraded (7%) at the end of the test period. The reference substance was degraded according to the validity criteria . In the toxicity control, the degradation was similar to the individual sets. Thus, no toxicity to sewage sludge microorganisms was observed. Therefore, the test substance is not ready biodegradable.
The study was perfomed under GLP (Schering report X578, 21 Nov 2001).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
