Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study, predates GLP, available as unpublished report, minor limitations in reporting but otherwise adequate for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyloxirane
EC Number:
200-879-2
EC Name:
Methyloxirane
Cas Number:
75-56-9
Molecular formula:
C3H6O
IUPAC Name:
2-methyloxirane
Details on test material:
No data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Carworth Farm E , Manor Farm
- Age at study initiation: 12 weeks
- Weight at study initiation: 150-250 gram
- Fasting period before study: 4 pm- 10am
- Housing: 5 per cage
- Diet : ad libitum after dosing
- Water : ad libitum
- Acclimation period:14 days


ENVIRONMENTAL CONDITIONS
recorded but reported


Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
all liquids were given undiluted by intubation in single doses on a ml/kg basis.
Doses:
in ml/kg not specified; only reported as LD50
No. of animals per sex per dose:
5
Control animals:
not specified
Statistics:
By probit analysis. and by use of Weil's tables of moving averages.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
382 - 587 mg/kg bw
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data

Any other information on results incl. tables

No details on findings were reported, except the LD 50 values.

Applicant's summary and conclusion