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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

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Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
The particle size distribution of calcium carbonate (amorphous form) has been determined.
GLP compliance:
no
Type of method:
sedimentation (gravitational settling)
Type of distribution:
volumetric distribution
Percentile:
D50
Mean:
1.494 µm
Remarks on result:
other: Std dev 1.425(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)
Percentile:
other: 95.0%
Mean:
< 2.414 µm
Remarks on result:
other: N/A
Percentile:
other: 84.0%
Mean:
< 1.977 µm
Remarks on result:
other: N/A
Percentile:
other: 50.0%
Mean:
< 1.494 µm
Remarks on result:
other: N/A
Percentile:
other: 16.0%
Mean:
< 1.127 µm
Remarks on result:
other: N/A
Percentile:
other: 5.0%
Mean:
< 0.908 µm
Remarks on result:
other: N/A
Conclusions:
The particle size distribution data indicates that 95% of calcium carbonate (amorphous form) particles have a diameter of <2.414 µm and therefore can be considered to be potentially inhalable.
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
The particle size distribution of calcium carbonate (aragonite form) has been determined.
GLP compliance:
no
Type of method:
sedimentation (gravitational settling)
Type of distribution:
volumetric distribution
Percentile:
D50
Mean:
0.419 µm
Remarks on result:
other: Std dev 2.136(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)
Percentile:
other: 95.0%
Mean:
< 2.849 µm
Remarks on result:
other: N/A
Percentile:
other: 84.0%
Mean:
< 0.89 µm
Remarks on result:
other: N/A
Percentile:
other: 50.0%
Mean:
< 0.419 µm
Remarks on result:
other: N/A
Percentile:
other: 16.0%
Mean:
< 0.258 µm
Remarks on result:
other: N/A
Percentile:
other: 5.0%
Mean:
< 0.205 µm
Remarks on result:
other: N/A
Conclusions:
The particle size distribution data indicates that 95% of calcium carbonate (aragonite form) particles have a diameter of <2.849 µm and therefore can be considered to be potentially inhalable.
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
The particle size distribution of calcium carbonate (bulk form) has been determined.
GLP compliance:
no
Type of method:
other: Two separate methods were used - laser diffraction and sedimentation
Type of distribution:
volumetric distribution
Specific details on test material used for the study:
Bulk CaCO3
Percentile:
D50
Mean:
< 1.8 µm
Remarks on result:
other: Determined with a Sedigraph 5100
Percentile:
D50
Mean:
< 2.6 µm
Remarks on result:
other: Determined with a Sympatec HELOS
Percentile:
other: 57%
Mean:
< 2 µm
Remarks on result:
other: Determined with a Sedigraph 5100
Percentile:
other: 38%
Mean:
< 2 µm
Remarks on result:
other: Determined with a Sympatec HELOS
Conclusions:
The particle size distribution data indicates that the d50% of calcium carbonate (bulk form) particles is <1.8 µm and therefore can be considered to be potentially inhalable.

Description of key information

Bulk calcium carbonate is potentially inhalable based on the particle size distribution of commercial grades.

Additional information