Registration Dossier
Registration Dossier
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EC number: 271-516-3 | CAS number: 68583-51-7
Endpoint summary
Administrative data
Description of key information
The hazard assessment is based on the data currently available. Pursuant to ECHA decision on a compliance check CCH-D-2114546495-41-01/F new studies with the registered substance will be conducted in the future. The finalised studies will be reported in an updated dossier until 19 October 2022 and the hazard assessment will be re-evaluated accordingly.
For further details, please refer to the category concept document attached to the category object (linked under IUCLID section 0.2) showing an overview of the strategy for all substances within the glycol esters category.
Additional information
The hazard assessment is based on the data currently available. Pursuant to ECHA decision on a compliance check CCH-D-2114546495-41-01/F new studies with the registered substance will be conducted in the future. The finalised studies will be reported in an updated dossier until 19 October 2022 and the hazard assessment will be re-evaluated accordingly.
For further details, please refer to the category concept document attached to the category object (linked under IUCLID section 0.2) showing an overview of the strategy for all substances within the glycol esters category.
Short-term studies with freshwater species from all three trophic levels (algae, aquatic invertebrates and fish) are available.
One acute toxicity guideline study to fish is available for decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7). No effects were observed up to the limit of water solubility.
The same result was found in a short-term toxicity study with aquatic invertebrates for decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7). No toxicity was observed up to the limit of water solubility in the available studies.
One standard guideline study investigating the toxicity to aquatic algae is available for the substance decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7). No toxicity was observed up to the limit of water solubility.
One long-term study with Daphnia magna is available for the category member butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) resulting in a NOEC (21 d) > water solubility. This study was used as read-across based on structural similarities. Moreover, it can be concluded that this substance can be seen as a worst case read-across approach based on the smaller fatty acid chain lengths which probably exhibits a higher water solubility since the hydrocarbon chain lengths of the fatty acid is directly correlated with the water solubility.
Toxicity to microorganisms was investigated in two studies for decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) and butylene glycol dicaprylate / dicaprate (CAS 853947-59-8), respectively. The first study with decanoic acid, mixed diesters with octanoic acid and propylene glycol was not considered to be reliable since only one single species (Pseudomonas putida) was tested. Nevertheless, no effects on O2-consumption were observed. The result from the second study with butylene glycol dicaprylate / dicaprate according to an accepted guideline was considered valid. No effects on respiration of activated sludge microorganisms were observed. In combination with results from the available biodegradation studies it can be concluded that no effects on the STP microorganism community and the subsequent degradation process in sewage treatment plants is anticipated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
