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EC number: 231-536-5
CAS number: 7620-77-1
All of the substances in the lithium salts of
monocarboxylic acids C14-C22 category are considered to be readily
The substances in the lithium salts of
monocarboxylic acids C14 -C22 category consist of a lithium cation and
an organic fatty acid anion. The substances in the category meet the
criteria for readily biodegradability though the biodegradation of the
substances is relevant only to the organic section. Fatty acids
biodegrade readily and completely according to the β-oxidation pathway
including three major steps (activation in the cytosol, transport into
mitochondria, β-Oxidation until the entire C-chain is cleaved into
acetyl CoA units). The final breakdown products of the substances are
carbon dioxide and water from the fatty acid anion and lithium from the
cation. Thus, stable degradation products are not being formed in the
environment. According to column 2 of REACH Annex VII, the ready
biodegradability study of the lithium cation does not need to be
conducted as the substance is inorganic. Readily biodegradability has
also been demonstrated for fatty acid salts with other cations, such as
sodium and potassium.
Proprietary data are available for lithium
behenate showing ready biodegradability (Harlan 2013). Published data
are available on lithium 12-hydroxystearate from regulatory reviews
(MITI 1994, API 2008) showing ready biodegradability. The results from
these studies also indicate that the lithium ion is not inhibitory to
microorganisms, and does not prevent the ready biodegradation of the
fatty acid component. Mizuki et al (2010) has been read across to the
category, showing that a mixture of ~60% sodium oleate (C18) and ~40%
potassium laurate (C12) is readily biodegradable. This indicates that
shorter carbon chain length substances are expected to have the same
properties as those of longer chain substances.
Experimental data on category members and
data on other metal salts of fatty acids in the carbon number range of
the category have been read across within the category. Substances with
shorter carbon chain lengths are expected to be more water soluble and
therefore more bioavailable to aquatic microorganisms for degradation.
Reading across from longer chain length substances to shorter chain
length substances is therefore considered valid. Therefore, all of the
substances in the lithium salts of monocarboxylic acids C14-C22 category
are considered to be readily biodegradable.
To support this conclusion, ready
biodegradation studies are currently being conducted on lithium
myristate, in order to bracket the category, and fatty acids C16 -18
(even numbered) saturated and C16 -20 (even numbered) unsaturated
lithium salts, to provide data on unsaturated structures (Charles River
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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