Registration Dossier
Registration Dossier
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EC number: 231-838-7 | CAS number: 7758-29-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment (test predominantly on effects on cadmium toxicity)
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of the chelating agent sodium tripolyphosphate on cadmium toxicity in mice
- Author:
- Andersen O, Hägerstrand I and Nordberk GF
- Year:
- 1 982
- Bibliographic source:
- Environmental research 29: 54-61
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Effects of sodium tripolyphosphate on cadmium toxicity administered subcutaneously were studied.
Animals were administered 30µmole/kg cadmium, 30µmole/kg CD + 90µmole STTP and 90µmole/kg STPP
Animals given STTP alone were sacrificed 24h post administration and the liver prepared for histological evaluation. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Pentasodium triphosphate
- EC Number:
- 231-838-7
- EC Name:
- Pentasodium triphosphate
- Cas Number:
- 7758-29-4
- Molecular formula:
- H5O10P3.5Na
- IUPAC Name:
- pentasodium bis(phosphonatooxy)phosphinate
- Details on test material:
- - Name of test material (as cited in study report): Sodium tripolyphosphate (STPP)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: 3-4 months
- Weight at study initiation: 30.0-34.9g
- Housing:Plastic cages
- Diet: Rostock mixture rat pellets ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- other: 0.9% NaCl
- Doses:
- 90µmole/kg
- No. of animals per sex per dose:
- 6 STPP
10 Cd + STPP - Control animals:
- no
- Statistics:
- Student's t test
Results and discussion
- Mortality:
- 7/10 animals receiving 30µmole/kg Cd + 90µmole/mg STPP
0/6 animals receiving 90µmole/kg STPP - Gross pathology:
- All animals had normal livers
Any other information on results incl. tables
No effects were reported at 90µmole/kg
Animals treated with cadmium and STPP suffered greater effects than animals administered with cadmium alone or STPP alone.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
