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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Remarks:
.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Test material was sieved in an alpine air jet sieving machine.
GLP compliance:
no
Type of method:
sieving
Type of distribution:
volumetric distribution
Percentile:
D50
Remarks on result:
other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
No.:
#1
Size:
< 45 µm
Distribution:
ca. 50 %
Conclusions:
The substance is considered to pose an inhalation risk (as a significant number of particles are present at <100µm in diameter).

This study is considered to be acceptable and to adequately satisfy both the guideline requirement and the regulatory requirement as a key study for this endpoint.

Description of key information

Two studies exist (company test data and MMAD as reported in an inhalation study). The company data has been selected as a key study as this is most representative of the substance that is placed on the market.

Additional information

Ca. 50% of the particles were found to be <45µm.