Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
Assessment of the scoring did not include 72 hours exposure
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Silicon tetrachloride
EC Number:
233-054-0
EC Name:
Silicon tetrachloride
Cas Number:
10026-04-7
Molecular formula:
Cl4Si
IUPAC Name:
tetrachlorosilane
Details on test material:
- Name of test material (as cited in study report): Silicon tetrachloride
- Substance type: Organosilane
- Physical state: liquid
- Analytical purity: No data
No further information available

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact and abraded
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
Four hours
Observation period:
48 hours
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 4, 24 and 48 hours
Score:
ca. 4.22
Max. score:
8
Reversibility:
no data
Remarks on result:
other: Intact and abraded skin. See Executive summary for calculation.
Irritation parameter:
erythema score
Remarks:
Intact skin
Basis:
animal #1
Time point:
24/48 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
erythema score
Remarks:
Intact skin
Basis:
animal #2
Time point:
24/48 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
erythema score
Remarks:
Intact skin
Basis:
animal #3
Time point:
24/48 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
erythema score
Remarks:
Intact skin
Basis:
animal #4
Time point:
24/48 h
Score:
1.5
Max. score:
4
Reversibility:
not reversible
Remarks on result:
no indication of irritation
Irritation parameter:
erythema score
Remarks:
Intact skin
Basis:
animal #5
Time point:
24/48 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
erythema score
Remarks:
Intact skin
Basis:
animal #6
Time point:
24/48 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Remarks:
Intact skin
Basis:
animal #1
Time point:
24/48 h
Score:
3.5
Max. score:
4
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
edema score
Remarks:
Intact skin
Basis:
animal #2
Time point:
24/48 h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
edema score
Remarks:
Intact skin
Basis:
animal #3
Time point:
24/48 h
Score:
4
Max. score:
4
Remarks on result:
positive indication of irritation
Irritation parameter:
edema score
Remarks:
Intact skin
Basis:
animal #4
Time point:
24/48 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Remarks:
Intact skin
Basis:
animal #5
Time point:
24/48 h
Score:
3.5
Max. score:
4
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
edema score
Remarks:
Intact skin
Basis:
animal #6
Time point:
24/48 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: scores at 24/48/72 hours were not given.
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: scores at 24/48/72 hours were not given.
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Remarks on result:
other: scores at 24/48/72 hours were not given.
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: scores at 24/48/72 hours were not given.
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: scores at 24/48/72 hours were not given.
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Remarks on result:
other: scores at 24/48/72 hours were not given.
Other effects:
In five of six animals tested, there was evidence of corrosivity (grade 3 (one animal) or 4 (four animals) erythema) at 48 hours post-treatment. No skin reaction was observed in the sixth animal, but this is unexpected, and considered as unreliable result.

Applicant's summary and conclusion

Interpretation of results:
Category 1A (corrosive) based on GHS criteria
Conclusions:
In the in vivo skin irritation study, conducted using a protocol similar to OECD Test Guideline 404 but pre-GLP, silicon tetrachloride was concluded to be corrosive to skin.