Registration Dossier
Registration Dossier
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EC number: 203-492-7 | CAS number: 107-46-0
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original study report not available for review.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Dow Corning, Health Care Research S.O.P. Nos. 407 and 408
- GLP compliance:
- yes
Test material
- Reference substance name:
- Hexamethyldisiloxane
- EC Number:
- 203-492-7
- EC Name:
- Hexamethyldisiloxane
- Cas Number:
- 107-46-0
- Molecular formula:
- C6H18OSi2
- IUPAC Name:
- trimethyl[(trimethylsilyl)oxy]silane
Constituent 1
Results and discussion
Any other information on results incl. tables
A distinct cytopathic effect was observed by the test substance in initial and retesting of the samples.
Applicant's summary and conclusion
- Conclusions:
- In an in vitro assay (reliability score 4), hexamethyldisiloxane produced a distinct cytopathic effect in initial testing and retesting of the samples in human embryonic cells.
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