Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: clinical observations
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient details to determine reliability

Data source

Reference
Reference Type:
publication
Title:
No data
Author:
Vrba, J.
Year:
1956
Bibliographic source:
Pracovni Lekarstvi, Vol 8, 210

Materials and methods

Study type:
other: Direct observation
Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexamethyldisiloxane
EC Number:
203-492-7
EC Name:
Hexamethyldisiloxane
Cas Number:
107-46-0
Molecular formula:
C6H18OSi2
IUPAC Name:
trimethyl[(trimethylsilyl)oxy]silane

Method

Subjects:
No data
Route of exposure:
inhalation
Reason of exposure:
intentional

Results and discussion

Clinical signs:
Inhalation of the vapor of hexamethyldisiloxane by humans was reported to produce a slight irritation of the lungs, skin and eyes.

Applicant's summary and conclusion

Conclusions:
In a clinical assessment (reliability score 4), inhalation of the vapor of hexamethyldisiloxane by humans was reported to produce a slight irritation of the lungs, skin and eyes.