2-(2-aminoethylamino)ethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study was performed prior to the implementation of GLP and OECD Guidelines, but is in compliance with the principles described in OECD Guideline 403. Observation period is not reported.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1970

Report date:

1970

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

not applicable

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-(2-aminoethylamino)ethanol

EC Number:

203-867-5

EC Name:

2-(2-aminoethylamino)ethanol

Cas Number:

111-41-1

Molecular formula:

C4H12N2O

IUPAC Name:

2-[(2-aminoethyl)amino]ethan-1-ol

Details on test material:

AEEA, degree of purity 99-100 %

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

Several groups of usually 3 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for different time periods ( 8 hours). The exposure time not causing lethality was usually testedtwice.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

saturated atmosphere at 20 °C.

No. of animals per sex per dose:

3 rats (total of 12 rats)

Control animals:

no

Details on study design:

- The animals were observed for signs of toxicity and mortality.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC0

Effect level:

51.3 mg/m³ air

Exp. duration:

8 h

Remarks on result:

other: saturated atmosphere

Mortality:

No mortality (0/12) was seen.

Gross pathology:

Apart from strong eye irritation no findings were noted at necropsy.

Other findings:

- Other observations: Animals tried to escape upon start of exposure. 

Any other information on results incl. tables

Effect level:

Animals were exposed to AEEA in a saturated atmosphere at 20 °C. No exposure concentration was reported. As the vapour pressure of AEEA is 0.012 hPa at 20 °C (calculated), a saturated atmosphere corresponds to 51.3 mg/m³.

Applicant's summary and conclusion

Executive summary:

In this acute inhalation toxicity study a total of 12 rats (two times 3/sex) were whole body exposed to AEEA (saturated atmosphere at 20 °C) for 8 hours. Animals then were observed. Animals tried to escape upon start of exposure. No mortality occured. Apart from strong eye irritation no findings were noted at necropsy.