Registration Dossier
Registration Dossier
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EC number: 200-860-9 | CAS number: 75-31-0
Endpoint summary
Administrative data
Description of key information
The substance has a low adsorption potential on soil (Koc: 43.2 L/kg). Volatility from water or moist soil will be low as well based on a Henry's law constant of 0.001615 Pa*m^3/mol (SPARC; pH 7; 25°C).
Additional information
There is no substantial adsorption potential to soil, based on the very low partition coefficient as well as ready biodegradability. Experimental Koc values were obtained with n-butylamine (source), a structure-analogous short-chain alkylamine [CAS no. 109-73-9]. From a reliable batch equilibrium test a very low potential for adsorption was determined based on three very different soils (2 soils, one sediment) with regard to pH, organic carbon content, sand, silt and clay content.
Overall result: Koc (geometric mean over three matrices) = 43.2 L/kg (Koc-range: 33.8 to 65.6 L/kg).
With a pKa of 10.8, isopropylamine will exist predominantly in its protonated form in the environment, and the protonated form of isopropylamine is not expected to volatilize from water or moist soil surfaces. Therefore, common estimation methods (including estimation from water solubility and vapour pressure) will overestimate volatility considerably. Therefore, SPARC was used to calculate Henry's law constant as a function of pH. The resulting Henry's law constant (SPARC; pH 7; 25°C) of 0.001615 Pa*m^3/mol confirms the assumed very low volatility in the environmentally relevant pH range.
In conclusion, isopropylamine will neither to any relevant extent adsorb to the solids fraction of STP sludge, water, sediment or soil, nor volatilize from water or moist soil. It will be found predominantly in the water phase.
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