Registration Dossier
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EC number: 701-374-4 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis studies have been conducted on two related phosphite chemicals - triisodecyl phosphite (TDP) and triphenyl phosphite (TPP). Based on the results of these experiments and other sources, this substance is anticipated to rapidly hydrolyze in water with a half-life of <1 day.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 17 h
- at the temperature of:
- 22 °C
Additional information
Al-Lohedan et al., (1991) reported a TPPi hydrolysis half-life of 1.1 h in water at pH 1.3 and 25 °C by extrapolation of results on TPPi solutions in ethanol/water. The results of BCRI experiments on aqueous/cosolvent TPPi solutions indicated that the half-lives of TPPi in deionized water (initially at pH 6 - 7) and pH 9 buffer were approximately 0.5 h and less than 14 h respectively, at 22 °C. Wang (2017) found similar half-lives for TPPi at 20 °C; the estimated DT50 of TPP in sterile buffer solutions was 21.9, 6.5, and 0.43 hours, respectively for pH 4.09, 7.05, and 8.99.
It was also observed that TDP hydrolyzed fairly rapidly at 23 C in aqueous/acetonitrile (1/1) solutions, with half-lives ranging from 4 to 20 hours over a pH range of 5 to 9 respectively. As such it is anticipated that the component chemicals of this substance (DDPP, TDP, DPDP) will hydrolyze rapidly with half-lives ranging from about an hour to 20 hours (at higher pH). At normal pH (7) this class of phosphites all had halves in the range of 0.5 - 20 hrs.
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