Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-645-3 | CAS number: 2210-79-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the O.E.C.D. test guideline 402 with GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,3-epoxypropyl o-tolyl ether
- EC Number:
- 218-645-3
- EC Name:
- 2,3-epoxypropyl o-tolyl ether
- Cas Number:
- 2210-79-9
- Molecular formula:
- C10H12O2
- IUPAC Name:
- oxirane
- Reference substance name:
- Oxirane, 2-[(2-methylphenoxy)methyl]-
- IUPAC Name:
- Oxirane, 2-[(2-methylphenoxy)methyl]-
- Details on test material:
- As per IUCLID Sections 1.1. 1.2. and 4.1.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Sprague-Dawley strain rats were supplied by Bantin & Kingman Ltd., Grimston, Aldborough, Hull, U.K. At the start of the study the males weighed 202 - 223 gm, and the females 200 - 219 gm, and were approximately ten to fourteen weeks old. After a minimum acclimatisation period of at least five days the animals were placed on study.
The animals were housed individually in solid-floor polypropylene cages during the 24-hour exposure period. For the remainder of the study the animals were housed in groups of five by sex in polypropylene grid-floor cages suspended over trays lined with absorbent paper. Free access to mains drinking water and food (Rat and Mouse Expanded Diet No. 1, Special Diet Services Limited, Witham, Essex, U.K.) was allowed throughout the study, except the day brfore exposure.
The animal room was maintained at a temperature of 20 - 23°C and relative humidity of 53 - 69%. The rate of air exchange was approximately 15 changes per hour and the lighting was controlled by a time switch to give 12 hours continuous light and 12 hours darkness.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- On the day before treatment the back and flanks of each animal were clipped free of hair using veterinary clippers to expose a skin area of approximately 5 cm x 4 cm. The calculated volume of the undiluted test substance, was applied uniformly to an area of shorn skin approximating to 10% of the total body surface area using a graduated syringe. A piece of aluminium foil measuring 7 cm x 4 cm was placed over the treatment area and occluded with a piece of self-adhesive bandage (HYPERTIE). The strapping was further secured with a piece of BLENDERM wrapped around each end. The animals were caged individually for the 24-hour exposure period.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/Kg of body weight.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Shortly after dosing the dressings were examined to ensure that they were securely in place. After the 24-hour contact period the strapping and foil were carefully removed and the treated skin and surrounding hair wiped with cotton wool moistened with distilled water to remove any residual test material. The animals were returned to group housing for the rest of the study.
Deaths and overt signs of toxicity were recorded , 1, 2 and 4 hours after dosing and subsequently at least once daily for 14 days. Individual bodyweights were recorded on the day of treatment (day 0) and on days seven and fourteen.
At the end of the studyperiod the animals were sacrificed by cervical dislocation and subjected to gross pathologic examination for any macroscopic abnormalities. This consisted of opening the abdominal and thoracic cavities and examining all major organs. The macroscopic appearance of abnormal organs if present was recorded. - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: None
- Gross pathology:
- No findings.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- No adverse findings were made in the study. The rat acute dermal LD50 for the test substance is > 2000 mg/Kg of body weight. The test substance is non-toxic by the dermal route of exposure in the rat.
- Executive summary:
The test substance, 2,3 -epoxypropyl o-tolyl ether was evaluated for acute dermal toxicity in the rat by an O.E.C.D. test guideline no. 402 study.No adverse findings were made in the study. The rat acute dermal LD50 for the test substance is > 2000 mg/Kg of body weight. The test substance is non-toxic by the dermal route of exposure in the rat.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
