Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

Under the conditions of this study, the administration of 2, 3-epoxypropyl o-tolyl ether (EPOTE) at actual dose levels up to and including 500 mg/kg/day was evaluated as negative for the induction of cII mutants in liver and testes of Big Blue® mice.


Short description of key information:
The test substance, 2,3-epoxypropyl o-tolyl ether was accessed for in vitro genotoxicity in two independent Ames/Salmonella mutation tests and an in vitro huiman lymphocyte DNA repair UDS study. Potential in vivo genotoxicity was evaluated in two mouse micronucleus (chromosome damage) studies, a male mouse dominate lethal assay and 2 MutaMouse gene-mutation assay in bone marrow, liver, skin or liver and testes.

Endpoint Conclusion: Adverse effect observed (negative)

Justification for classification or non-classification

The weight-of-evidence demonstrates that there is insufficient in vivo genotoxicity evidence to Classify and Label the test substance as a Mutagen.