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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook.

Data source

Reference
Reference Type:
review article or handbook
Title:
Pschyrembel Klinisches Wörterbuch
Author:
Pschyrembel, W.
Year:
2012
Bibliographic source:
De Gruyter Publishing, 263rd ed., 2012

Materials and methods

Type of study / information:
Clinical dictionary
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
not applicable
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Not applicable, general physiological information

Results and discussion

Any other information on results incl. tables

Bile salts:

Components of bile synthesised in the liver from cholesterol. They can be subdivided into primary bile salts cholate and chenodeoxycholate and the secondary bile salts deoxycholate and lithocholate. They can be conjugated to glycine or taurine forming glycocholate and taurocholate, respectively, and are recycled 6-8 times per day in the enterohepatic cycle. Functions: They aid in the emulsification of triglycerides, activate digestive enzymes by shift of the pH-value and have an influence on the peristalsis of small intestines and colon (inhibition and stimulation, respectively).

Chylomicrons:

Lipoprotein particles of low density with a high level of lipids (98-99.5%; remaining fraction: apolipoproteins) which are synthesised in the gut mucosa. They are transported into the blood via the lymphatic system (thoracic duct) and carry triglycerides absorbed from foods. The triglycerides in the chylomicrons are degraded by endothelial lipoprotein lipase in the blood vessels, leading to formation of chylomicron remnants, which are precursors for VLDL and HDL in the liver.

Thoracic duct:

The thoracic duct drains the lymph of the complete lower and left upper parts of the body into the bloodstream at the left venous angle.

Applicant's summary and conclusion