Registration Dossier
Registration Dossier
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EC number: 629-695-4 | CAS number: 164383-22-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
These results from Coconitrile can be regarded as valid for Tallownitrile as the tested substance is actually the same:They share the same chemical structure, and only differ in the average length of the alkyl chain. Aspects of sensitization are related to possible dermal penetration, and subsequent reactivity and protein binding (needed for haptenisation) which are properties that are relative independent to actual chain length. If anything, it is assumed that shorter chain lengths are possibly somewhat more bio-available, and thus the testing of Coconitrile might represent a worse case situation compared to Tallow.
Migrated from Short description of key information:
A GPMT study with Coconitrile showed no concern for sensitisation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
GPMT study on coconitrile performed under GLP and according to OECD guideline 406 resulted to a weak reaction in only 10% of the animals. Accordingly, no classification is required for dermal sensitisation. As chemical respiratory sensitisers also elicit positive results in predictive tests for contact sensitisation, the negative outcome for dermal sensitisation is also predictive for non respiratory sensitisation of the substance.
Migrated from Short description of key information:
A GPMT study with Coconitrile showed no concern for sensitisation.
Justification for classification or non-classification
A standard study to evaluate the sensitsing potential of coconitrile indicated that no classification is required for skin sensitisation. As such tests are also positive when tested with respiratory sensitisers, the non-sensitisng results of this tests also indicate that the substance is also not a respiratory sensitiser.
These results from Coconitrile can be regarded as valid for Tallownitrile as the tested substance is actually the same:They share the same chemical structure, and only differ in the average length of the alkyl chain. Aspects of sensitization are related to possible dermal penetration, and subsequent reactivity and protein binding (needed for haptenisation) which are properties that are relative independent to actual chain length. If anything, it is assumed that shorter chain lengths are possibly somewhat more bio-available, and thus the testing of Coconitrile might represent a worse case situation compared to Tallow.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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