Registration Dossier
Registration Dossier
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EC number: 402-070-1 | CAS number: 88122-99-0 UVINUL T 150
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: SNIF file released by ECHA
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Objective of study:
- other: To examine the skin penetration of a 5% (w/w) formulation of the test substance after a single application
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Penetration through human epidermis in vitro
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
- EC Number:
- 402-070-1
- EC Name:
- Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
- Cas Number:
- 88122-99-0
- Molecular formula:
- C48H66N6O6
- IUPAC Name:
- 2-ethylhexyl 4-({4,6-bis[(4-{[(2-ethylhexyl)oxy]carbonyl}phenyl)amino]-1,3,5-triazin-2-yl}amino)benzoate
- Test material form:
- solid: particulate/powder
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: Samples of human epidermis
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- other: 5% test substance in a sunscreening product formulation
- Control animals:
- no
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- not measured
Any other information on results incl. tables
Approx. 0.1% (= approx. 0.05 ug/cm^2) at the high dose (10 mg of the preparation/cm^2) and approx. 1.3% (= approx 0.065 ug/cm^2) at the low dose (1 mg of the preparation/cm^2) have penetrated the epidermis 24 hours after application.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
