Registration Dossier

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only abstract is available.

Data source

Reference
Reference Type:
publication
Title:
In vivo micronucleus test in mice with 1-phenylethanol (abstract only)
Author:
Engelhardt G
Year:
2006
Bibliographic source:
Archives of toxicology.80(12):868-872.

Materials and methods

GLP compliance:
not specified
Type of assay:
micronucleus assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Duration of treatment / exposure:
Single exposure.
Frequency of treatment:
Single exposure.
Post exposure period:
(samling of bone marrow) 24 and 48 hours after the treatment.
No. of animals per sex per dose:
No data.
Control animals:
not specified

Examinations

Tissues and cell types examined:
Bone marrow.

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
negative
Toxicity:
yes
Remarks:
More than 750 mg/kg bw
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
Under the experimental conditions used in mice, there was no evidence of increased micronuclei frequencies at any dose or sampling time. These findings indicate that 1-phenylethanol is not clastogenic in vivo.
Executive summary:

Under the experimental conditions used in mice, there was no evidence of increased micronuclei frequencies at any dose or sampling time. These findings indicate that 1-phenylethanol is not clastogenic in vivo. Only abstract is available therefore a reliability of 4 is assigned.