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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only abstract is available.

Data source

Reference
Reference Type:
publication
Title:
In vivo micronucleus test in mice with 1-phenylethanol (abstract only)
Author:
Engelhardt G
Year:
2006
Bibliographic source:
Archives of toxicology.80(12):868-872.

Materials and methods

GLP compliance:
not specified
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
1-phenylethanol
EC Number:
202-707-1
EC Name:
1-phenylethanol
Cas Number:
98-85-1
Molecular formula:
C8H10O
IUPAC Name:
1-phenylethan-1-ol

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Duration of treatment / exposure:
Single exposure.
Frequency of treatment:
Single exposure.
Post exposure period:
(samling of bone marrow) 24 and 48 hours after the treatment.
No. of animals per sex per dose:
No data.
Control animals:
not specified

Examinations

Tissues and cell types examined:
Bone marrow.

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
negative
Toxicity:
yes
Remarks:
More than 750 mg/kg bw
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
Under the experimental conditions used in mice, there was no evidence of increased micronuclei frequencies at any dose or sampling time. These findings indicate that 1-phenylethanol is not clastogenic in vivo.
Executive summary:

Under the experimental conditions used in mice, there was no evidence of increased micronuclei frequencies at any dose or sampling time. These findings indicate that 1-phenylethanol is not clastogenic in vivo. Only abstract is available therefore a reliability of 4 is assigned.