Registration Dossier
Registration Dossier
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EC number: 211-659-0 | CAS number: 682-01-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h): >201 mg/l mortality Brachydanio rerio Rel. 2 (Read-across from CAS 18765-38-3)
LC50 (96 h): >245 mg/l mortality Brachydanio rerio Rel. 2 (Read-across from CAS 78-10-4)
LC50 (48 h): 3200 mg/l mortality Oncorhynchus mykiss (from EU Risk Assessment for Propanol)
Key value for chemical safety assessment
Additional information
There are no short-term data for toxicity of the registered substance to fish. However data are available for two structurally-analogous read-across substances; tetrakis(2-butoxyethyl) orthosilicate (CAS 18765 -38 -3) and tetraethyl orthosilicate (CAS 78 -10 -4).
· A 96 hour LC50 value of >201 mg/l and NOEC of ≥201 mg/l have been determined for the effects of tetrakis(2-butoxyethyl) orthosilicate on mortality of Brachydanio rerio based on measured concentrations of dissolved organic carbon (DOC).
· A 96-hour LC50 of >245mg/l and a NOEC of ≥245 mg/l have been determined for the effects of tetraethyl orthosilicate on mortality of Brachydanio rerio based on measured concentrations of dissolved organic carbon (DOC).
Both of these substances hydrolyse in water and it is therefore likely that the test organisms were primarily exposed to their hydrolysis products.
The studies were conducted according to an appropriate OECD test guideline, and in compliance with GLP, and were considered to be reliability 1 (reliable without restrictions). Read across to the registered substance is considered scientifically justified; the read across is considered to be reliability 2. Further information on read-across is given in the Aquatic toxicity endpoint summary.
However, in view of the rapid hydrolysis of the registered substance to silicic acid and propanol and the absence of toxicicity to aquatic organisms of silicic acid, the PNECaquatic(freshwater)will be based on data for propanol.
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