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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

EC50 (48 h): >90 mg/l mobility Daphnia magna Rel. 2 (Read-across from CAS 18765-38-3)
EC50 (48 h): >75 mg/l mobility Daphnia magna Rel. 2 (Read-across from CAS 78-10-4)
EC50 (48 h): 1000 mg/l mortality Gammarus pulex (from EU Risk Assessment for Propanol)

Key value for chemical safety assessment

Additional information

There are no short-term data for toxicity of the registered substance to invertebrates. However data are available for two structurally-analogous read-across substances; tetrakis(2-butoxyethyl) orthosilicate (CAS 18765 -38 -3) and tetraethyl orthosilicate (CAS 78 -10 -4).

·        A 48-hour EC50 value of >90 mg/l and NOEC of ≥90 mg/l have been determined for the effects of tetrakis(2-butoxyethyl) orthosilicate on mobility of Daphnia magna based on nominal concentrations of the test substance.

·        A 48-hour LC50 of >75mg/l and a NOEC of ≥75 mg/l have been determined for the effects of tetraethyl orthosilicate on mobility of Daphnia magna based on measured concentrations of ethyl silicate. 

Both of these substances hydrolyse in water and it is therefore likely that the test organisms were primarily exposed to their hydrolysis products.

The studies were conducted according to an appropriate OECD test guideline, and in compliance with GLP. Read across to the registered substance is considered scientifically justified; the read across is considered to be reliability 2.

However, in view of the rapid hydrolysis of the registered substance to silicic acid and propanol and the absence of toxicicity to aquatic organisms of silicic acid, the PNECaquatic(freshwater)will be based on data for propanol.