Registration Dossier
Registration Dossier
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EC number: 203-571-6 | CAS number: 108-31-6
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This data was published in acadamic publication and the method is acceptable, so the result is reliable.
Data source
Reference
- Reference Type:
- publication
- Title:
- The hydrolysis of carboxylic anhydrides. Part III. Reactions in initially neutral solutions.
- Author:
- Bunton, C. A., Fuller, N. A., Perry, S. G., and Shiner, V. J.
- Year:
- 1 963
- Bibliographic source:
- J. Chem. Soc.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
Test material
- Reference substance name:
- Maleic anhydride
- EC Number:
- 203-571-6
- EC Name:
- Maleic anhydride
- Cas Number:
- 108-31-6
- Molecular formula:
- C4H2O3
- IUPAC Name:
- furan-2,5-dione
- Details on test material:
- Same with the substance notified in the section 1 of this dossier.
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- no
- Details on sampling:
- no data
- Buffers:
- no data
- Estimation method (if used):
- no data
- Details on test conditions:
- no data
- Number of replicates:
- no data
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- no data
Results and discussion
- Preliminary study:
- no data
- Test performance:
- no data
- Transformation products:
- yes
Identity of transformation products
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- but-2-enedioic acid
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 203-742-5]
- CAS number:
- 110-16-7
- Details on hydrolysis and appearance of transformation product(s):
- no data
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 7
- Temp.:
- 25.1 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- ca. 0.37 min
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 0 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- ca. 3.32 min
- Type:
- (pseudo-)first order (= half-life)
- Other kinetic parameters:
- no data
- Details on results:
- no data
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- full detailed the method and fulfilled the validity criteria
- Conclusions:
- The half-life of the hydrolysis of maleic anhydride to maleic acid in water at 25.1℃ is approximately 22 seconds.
- Executive summary:
This data was published in a famous acdamic publication, and the method is acceptable.
Maleic anhydride is readily hydrolyzed to maleic acid under aqueous conditions, the half-life of the hydrolysis of maleic anhydride to maleic acid in water at 25.1℃ is approximately 22 seconds, maleic acid is expected to be stable in water since there are no functional groups that would lead to further hydrolysis. The information can be used as a supporting study.
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