Registration Dossier
Registration Dossier
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EC number: 918-594-3 | CAS number: 7723-14-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The solubility and availability for absorption through the gut wall (bioaccessibility) of Red Phosphorus was determined in a model system that simulates the dynamic conditions in the gastro-intestinal tract of a fasted healthy human adult (TIM-1):
- The mean bioaccessibility of Red Phosphorus was 1.3 +/- 0.4% of the whole intake (10 g).
- The majority of Phosphorus is dialysed in the jejunal compartment during the first 120 min. of the experiment, suggesting that the dialysed Phosphorus species were readily available from the Red Phosphorus particles. This was expected, because the particles are always covered with small amounts of Phosphorus Oxy Acids (PO23-, PO33-, PO43 –).
- No elemental Phosphorus was present in the bioaccessible fractions. This is in agreement with the likelihood of undissolved elemental Phosphorus able to pass through the dialysis membrane.
Taking into account the results of the above mentioned bioaccessibility-study performed with Red Phosphorus, this substance is considered to be not systemically bioavailable itself. Only the oxidized Phosphorus species (PO23-, PO33-, PO43 –) are able to cross the gut wall and enter the organism in a minimal amount (1.3 % of the applied Phosphorus dose). These compounds are not known to be toxic but essential for several biochemical/metabolic mechanisms. There is no tendency for bioaccumulation of elemental Phosphorus and its oxidized species.
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