Registration Dossier
Registration Dossier
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EC number: 201-842-3 | CAS number: 88-60-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Reproduced from SIAR 6-tert-Butyl-m-cresol, 08.08.2002 from HPV/ICCA; peer reviewed report, secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Sumitomo Chemical (1988b)
- Year:
- 1 988
- Bibliographic source:
- cited: OECD SIDS Initial Assessment Report, Boston 20-25th Oct. 2002
Materials and methods
- Principles of method if other than guideline:
- Method: other: Draize's (scoring) and Kay & Calandra's (classification) method
- GLP compliance:
- yes
Test material
- Reference substance name:
- 6-tert-butyl-m-cresol
- EC Number:
- 201-842-3
- EC Name:
- 6-tert-butyl-m-cresol
- Cas Number:
- 88-60-8
- Molecular formula:
- C11H16O
- IUPAC Name:
- 2-tert-butyl-5-methylphenol
- Details on test material:
- Produced by Sumitomo Chemical, Lot No. 80159.Purity 98.5%.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Amount applied: 0.1 ml/eye
- Duration of treatment / exposure:
- unwashed eye: 24 h data available
unwashed eye: duration of application not mentioned - Observation period (in vivo):
- unknown, 24 h values available
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- no further data
Results and discussion
In vivo
- Other effects:
- no data
Any other information on results incl. tables
Extreme irritating was observed at 24 hr (MMTS: 58.3) after 0.1 ml/eye application(unwashed). In the washed group, irritating potency was judged to be moderate at 24 hr ( MMTS: 36.3 ).
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information
- Conclusions:
- Classification: risk of serious damage to eyes
- Executive summary:
method: Draize's (scoring) and Kay & Calandra's (classification) method
result: highly irritating (risk of serious damage to eyes)
reference: Sumitomo (1988)
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