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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

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Description of key information

The effect of 6-tert-butyl-m-cresol and other substituted phenols on liver weights and liver enzymes (hexabarbitone oxidase and aminopyrine demethylase) was determined in the rat. A significant increase in liver weight but no significant induction of liver enzymes was observed.

Additional information

in the case of 6 -tert-butyl-m-cresol no significant relationship between liver weight increase and enzyme induction was observed