Registration Dossier
Registration Dossier
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EC number: 204-337-6 | CAS number: 119-61-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In an acute toxicity study conducted comparable to OECD guideline 203 Pimephales promelas were exposed to benzophenone under flow-through conditions. The 96 h LC50 and EC50 (behaviour) values were determined to be 15.3 mg/L (test 1) and 14.2 mg/L (test 2). Based on the similar results, a mean 96 h LC50 and EC50 value of 14.75 mg/L was calculated.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 14.75 mg/L
Additional information
In a very well documented study, the acute toxicity to fish was investigated in a study conducted comparable to OECD guideline 203 'Fish, acute toxicity' under flow-through conditions. Two separate tests were performed in duplicate each and nominal concentrations applied in test 1 and 2 ranging from 0 to 21.9 mg/L (<0.24 to 23.8 mg/L effective). The actual concentrations were measured using GLC. Benzophenone shows toxicity towards Pimephales promelas: 96 h LC50 and EC50=15.3 mg/L (test 1), 96 h LC50 and EC50=14.2 mg/L (test 2). Based on the similar results, a mean 96 h LC50 and EC50 value of 14.75 mg/L was calculated. These results were supported by a study conducted according to a national guideline which, however, showed minor deficiencies in documentation. In a 7 d acute toxicity study performed under flow through conditions with freshly hatched larvae from Pimephales promelas, a 96-h LC50=10.89 mg a.i./L (measured) was determined. In a peer-reviewed databank. the results of a further acute toxicity study conducted according to OECD Guideline 203 are reported (96 -h LC50 > 10 mg test mat./L).
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